Soluble Tranferrin Receptor

Iron transport in the plasma is carried out by transferrin, which gives iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).
Iron uptake into cells is mediated through internalizing iron-transferrin complexes. The iron-transferrin complex binds to transferrin receptors exposed on the outer side of the plasma membrane and is internalized through endosomes with the ultimate release of iron into the cytoplasm.
A soluble form of the TfR (sTfR) has been identified in serum.
sTfR is a truncated monomer (70 kDa) of the tissue receptor, lacking its first 100 amino acids, which retains its transferrin binding activity. sTfR circulates as a complex of transferrin and its receptor.
The erythroblasts rather than reticulocytes are the primary source of serum sTfR.
The concentration of sTfR is an indicator of iron status.
Iron deficiency causes overexpression of transferrin receptor, and sTfR levels, while iron repletion results in decreased sTfR levels.
Blood testing of the soluble transferrin receptor (sTfR) is used as a measure of functional iron status, and for the investigation of iron deficiency anaemia.
Although ferritin measurement is the accepted method for assessing iron deficiency, it is an acute-phase reactant and increases in response to processes that do not correlate with iron status, including inflammation, chronic disease, malignancy, and infection.
sTfR is not an acute-phase reactant, and the interpretation of iron status using sTfR measurement is not affected by these confounding pathologies.
The test is useful for evaluating suspected iron deficiency in patients who may have inflammation, infection, or chronic disease and other conditions in which ferritin concentration does not correlate with iron status (1).

Reference

  1. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status Yves Beguin Clinica Chimica Acta 329 (2003) 9–2

For Beckman Coulter Immage® Analyzer

The Soluble Transferrin Receptor – Reagent “IMG” kit, when useed in when used in conjunction with the Beckman Coulter Immage® analysers , is intended for the determination of the Soluble Trasferrine Receptor (STR, sTfR) in human serum.
Kit code KR.IMG.STFR
Antiserum Reagent (Reagent 2)
Recettore solubile Transferrina – sTfR R.IMG.STFR 2 vials x 4,4 ml ●
Buffer (Reagent 1)
Reaction Buffer – sTfR R.IMG.STFR.BF 2 vials x 20 ml ●
Calibrator
Prediluted Calibrator Set
sTfR
Set of ready-to-use Calibrators		 W.SET.SPC.STFR 6 vials – 1 ml ▬
Controls
sTfR
High Value		 Y.SPR.STFR.HV 1 vial – 1 ml ▬
sTfR
Low Value		 Y.SPR.STFR.LV 1 vial – 1 ml ▬
Key
● Reagents included in the kit.
▬ Correlated reagents not included in the kit. They are available separately.

For Abbott Architect™ Analyzer

The Soluble Transferrin Receptor Reagent “ABT” kit, when used in conjunction with the Abbott Architect™ series (c4000 – c8000 – c16000) , is intended for the determination of the Soluble Trasferrine Receptor (STR, sTfR) in human serum.
Kit code KR.ABT.STFR
Antiserum Reagent (Reagent 2)
Soluble Tranferrin Receptor – sTfR R.ABT.STFR 1 vial x 4,4 ml ●
Buffer  (Reagent 1)
Reaction Buffer – sTfR R.ABT.STFR.BF 1 vial x 20 ml ●
Calibrator
Calibrator – sTfR W.SPC.STFR 1 vial – 1 ml ▬
Controls
sTfR
High Value		 Y.SPR.STFR.HV 1 vial – 1 ml ▬
sTfR
Low Value		 Y.SPR.STFR.LV 1 vial – 1 ml ▬
Key
● Reagents included in the kit.
▬ Correlated reagents not included in the kit. They are available separately.

For Abbott Alinity™  c Analyzer

The Soluble Transferrin Receptor Reagent “ABT” kit, when used in conjunction with the Abbott Alinity™ c Analyzer , is intended for the determination of the Soluble Trasferrine Receptor (STR, sTfR) in human serum.
Kit code KR.ABT.STFR-C02
Antiserum Reagent  (Reagent 2)
Soluble Tranferrin Receptor – sTfR R.ABT.STFR-C02 1 cartridge x 8 mL ●
Buffer  (Reagent 1)
Reaction Buffer – sTfR R.ABT.STFR.BF 1 cartridge x 20 mL ●
Calibrator
Calibrator – sTfR W.SPC.STFR 1 vial – 1 ml ▬
Controls
sTfR
High Value		 Y.SPR.STFR.HV 1 vial – 1 ml ▬
sTfR
Low Value		 Y.SPR.STFR.LV 1 vial – 1 ml ▬
Key
● Reagents included in the kit.
▬ Correlated reagents not included in the kit. They are available separately.