Retinol Binding Protein
Retinol-binding protein (RBP) is a single polypeptide chain, with a molecular weight of about 21-kDa, that is hepatically synthesized and responsible for transporting vitamin A from the liver to other tissues.
RBP has a 10-hour half-life and responds to both protein and calorie restrictions. It is typically more affected by energy restriction than by protein deficiency.
Since RBP is relatively unaffected by the acute inflammatory response, RBP appears to be a more reliable indicator of nutritional status following surgery or injury.
Serum RBP is altered in relation to metabolic syndrome (MetS), a constellation of metabolic abnormalities including central obesity, dyslipidaemia, elevated blood pressure, and hyperglycaemia (1). MetS is associated with an increased risk of type 2 diabetes mellitus and cardiovascular disease (CVD) (2, 3).
RBP is freely filtered by the glomerulus and subsequently reabsorbed and catabolized by the proximal tubule.
RBP is a highly sensitive indicator of renal tubule dysfunction and injury of various aetiologies, including antibiotic and environmental toxicant exposure.
It should be noted that serum RBP levels are depressed in vitamin A deficiency, and urinary levels may theoretically yield a false-negative result in this setting.
Reference
- Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr SC, Spertus JA, Costa F 2005. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752
- Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. 2002 Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 156:1070–1077
- Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT 2002. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709–2716
For Beckman Coulter Immage® Analyzer
RBP – Serum |
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Product code | ||
KR | KR.IMG.RBP-S | Reagent Kit (Calibrator and controls not included) |
K | K.IMG.RBP-S | Complete Kit |
KR | K | ||||
Antiserum Reagent | |||||
Retinol Binding Protein – Serum | R.IMG.RBP-S | 1 vial – 3,5 ml | ● | ● | |
Accessory Reagent | |||||
Reagent “B” RBP | R.IMG.RBP.B | 1 vial – 1 ml | ● | ● | |
Calibrators | |||||
Retinol Binding Protein | W.SPC.RBP | 1 vial – 1 ml | ▬ | ● | |
Prediluted Calibrator Set Retinol Binding Protein Set of ready-to-use Calibrators |
W.SET.SPC.RBP | 5 vials – 1 ml | ▬ | ▬ | |
Controls | |||||
Retinol Binding Protein – Serum Medium Value |
Y.SPR.RBP.MV | 1 vial – 1 ml | ▬ | ● | |
Retinol Binding Protein – Serum Low Value |
Y.SPR.RBP.LV | 1 vial – 1 ml | ▬ | ● | |
Retinol Binding Protein – Serum Medium Value |
Y.SPR.RBP.MV-3 | 3 vials – 1 ml | ▬ | ▬ | |
Retinol Binding Protein – Serum Low Value |
Y.SPR.RBP.LV-3 | 3 vials– 1 ml | ▬ | ▬ | |
Key | |||||
● | Reagents included in the kit. | ||||
▬ | Correlated reagents not included in the kit. They are available separately. |
RBP – Urine |
||
Product code | ||
KR | KR.IMG.RBP-U | Reagent Kit (Calibrator and controls not included) |
K | K.IMG.RBP-U | Complete Kit |
KR | K | ||||
Antiserum Reagent | |||||
Retinol Binding Protein – Urine | R.IMG.RBP-U | 1 vial – 4,7 ml | ● | ● | |
Accessory Reagent | |||||
Reagent “B” RBP | R.IMG.RBP.B | 1 vial – 1 ml | ● | ● | |
Calibrators | |||||
Retinol Binding Protein | W.SPC.RBP | 1 vial – 1 ml | ▬ | ● | |
Prediluted Calibrator Set Retinol Binding Protein Set of ready-to-use Calibrators |
W.SET.SPC.RBP | 5 vials – 1 ml | ▬ | ▬ | |
Controls | |||||
Retinol Binding Protein – Urine Medium Value |
Y.UPR.RBP.MV | 1 vial– 1 ml | ▬ | ● | |
Retinol Binding Protein – Urine Low Value |
Y.UPR.RBP.LV | 1 vial– 1 ml | ▬ | ● | |
Retinol Binding Protein -Urine Medium Value |
Y.UPR.RBP.MV-3 | 3 v – 1 ml | ▬ | ▬ | |
Retinol Binding Protein – Urine Low Value |
Y.UPR.RBP.LV-3 | 3 fiale – 1 ml | ▬ | ▬ | |
Key | |||||
● | Reagents included in the kit. | ||||
▬ | Correlated reagents not included in the kit. They are available separately. |