C1Q

C1q is a 480 kDa protein involved in the classical pathway of the complement cascade of the immunitary system contributing to the innate defence against infections.
Binding its targets, such as antigen-bound immunoglobulins or C-reactive protein, C1q leads to the release of inflammation stimulating peptides, C3a and C5a, to the formation of the opsonin C3b and to the formation of the membrane attack complex, resulting in target cell lysis. Furthermore, C1q is involved in phagocytosis or myeloid cell modulation and its circulating levels are determined in routine diagnostics as biomarker in several disease.
Decreased C1q levels are observed in some autoimmune conditions (such as Systemic lupus erythematosus (SLE), hypocomplementemic urticaria vasculitis syndrome, angioedema) and reflect the consumption of C1q by complement activation. For this reason, its quantification is useful as a marker for disease activity.
Instead, the increase of C1q levels in serum suggest the negative modulation of the adaptive immune response as C1q is well know to impact on the maturation status of antigen-presenting cells leading to decrease T-cell activity. High levels of C1q can be observed related to infectious and inflammatory disease (tuberculosis, sarcoidosis, leprosy, malaria) (1).

Reference

  1. Lubbers R, Sutherland JS, Goletti D, de Paus RA, van Moorsel CHM, Veltkamp M, Vestjens SMT, Bos WJW,Petrone L, Del Nonno F, Bajema IM,Dijkman K,Verreck FAW, Walzl G,Gelderman KA, Groeneveld GH,Geluk A, Ottenhoff THM, Joosten SA and Trouw LA (2018) Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis. Front. Immunol. 9:2427.doi: 10.3389/fimmu.2018.02427

For Beckman Coulter Immage® Analyzer
Product code
KR KR.IMG.C1Q Reagent Kit (Calibrator and controls not included)
K  K.IMG.C1Q Complete Kit
The C1q (C1Q) Reagent “IMG” Kit, when used in conjunction with Beckman Coulter Immage® Analyzer), is intended for the quantitative determination of C1q in human serum.
KR K
Antiserum Reagent
C1q R.IMG.C1Q 1 vial – 3,5 ml ● ●
Calibrators
Complement system proteins W.SPC.CS1 1 vial – 1 ml ▬ ●
Prediluted Calibrator Set
Complement system proteins
Set of ready-to-use Calibrators		 W.SET.SPC.CS1 5 vials – 1 ml ▬ ▬
Controls
Complement system proteins
Medium Value		 Y.SPR.CS1.MV 1 vial – 1 ml ▬ ●
Complement system proteins
Low Value		 Y.SPR.CS1.LV 1 vial – 1 ml ▬ ●
Complement system proteins
Medium Value		 Y.SPR.CS1.MV-3 3 vials – 1 ml ▬ ▬
Complement system proteins
Low Value		 Y.SPR.CS1.LV-3 3 vials – 1 ml ▬ ▬
Key
● Reagents included in the kit.
▬ Correlated reagents not included in the kit. They are available separately.

 

For Siemens serie BN™ Analyzer
Product code
KR KR.BNA.C1Q Reagent Kit (Calibrator and controls not included)
K  K.BNA.C1Q Complete Kit
The C1q “BNA” Kit, when used in conjunction with Siemens “BN™ series” Analyzers (BNA, BN100, BNII, ProSpec), is intended for the quantitative determination of C1q in human serum.
KR K
Antiserum Reagent
C1q R.BNA.C1Q 1 vial– 2 ml ● ●
Calibrator
Complement system protein W.SPC.CS1 1 vial – 1 ml ▬ ●
Controls
Complement system proteins
Medium Value		 Y.SPR.CS1.MV 1 vial – 1 ml ▬ ●
Complement system proteins
Low Value		 Y.SPR.CS1.LV 1 vial – 1 ml ▬ ●
Complement system proteins
Medium Value		 Y.SPR.CS1.MV-3 3 vials – 1 ml ▬ ▬
Complement system proteins
Low Value		 Y.SPR.CS1.LV-3 3 vials – 1 ml ▬ ▬
Key
● Reagents included in the kit.
▬ Correlated reagents not included in the kit. They are available separately.