{"id":1176,"date":"2017-01-02T09:38:20","date_gmt":"2017-01-02T08:38:20","guid":{"rendered":"https:\/\/newscientific.eu\/rbp\/"},"modified":"2025-05-15T11:35:35","modified_gmt":"2025-05-15T09:35:35","slug":"rbp","status":"publish","type":"page","link":"https:\/\/newscientific.eu\/en\/rbp\/","title":{"rendered":"RBP"},"content":{"rendered":"

Retinol Binding Protein<\/h2>\n

Retinol-binding protein (RBP) is a single polypeptide chain, with a molecular weight of about 21-kDa, that is hepatically synthesized and responsible for transporting vitamin A from the liver to other tissues.
\nRBP has a 10-hour half-life and responds to both protein and calorie restrictions. It is typically more affected by energy restriction than by protein deficiency.
\nSince RBP is relatively unaffected by the acute inflammatory response, RBP appears to be a more reliable indicator of nutritional status following surgery or injury.
\nSerum RBP is altered in relation to metabolic syndrome (MetS), a constellation of metabolic abnormalities including central obesity, dyslipidaemia, elevated blood pressure, and hyperglycaemia (1). MetS is associated with an increased risk of type 2 diabetes mellitus and cardiovascular disease (CVD) (2, 3).
\nRBP is freely filtered by the glomerulus and subsequently reabsorbed and catabolized by the proximal tubule.
\nRBP is a highly sensitive indicator of renal tubule dysfunction and injury of various aetiologies, including antibiotic and environmental toxicant exposure.
\nIt should be noted that serum RBP levels are depressed in vitamin A deficiency, and urinary levels may theoretically yield a false-negative result in this setting.<\/p>\n

Reference<\/em><\/small><\/p>\n

    \n
  1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr SC, Spertus JA, Costa F 2005. Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735\u20132752<\/em><\/li>\n
  2. Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. 2002 Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 156:1070\u20131077<\/em><\/li>\n
  3. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT 2002. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709\u20132716<\/em><\/li>\n<\/ol>\n

     <\/p>\n\n\n\n
    \n

    Search IFU<\/strong><\/span><\/h4>\n

    <\/p>\n


    \n
    \n
    \n
    \n
    \n
    \n<\/form>\n

    *Mandatory field<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    For Beckman Coulter Immage\u00ae 800 Analyzer<\/strong><\/span><\/h4>\n\n\n\n\n\n\n
    \n
    RBP – Serum<\/strong><\/h5>\n<\/td>\n<\/tr>\n
    <\/td>\nProduct code<\/strong><\/td>\n<\/tr>\n
    KR<\/strong><\/td>\nKR.IMG.RBP-S<\/td>\nReagent Kit (Calibrator and controls not included)<\/td>\n<\/tr>\n
    K\u00a0<\/strong><\/td>\nK.IMG.RBP-S<\/td>\nComplete Kit<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    The Retinol Binding Protein (RBP) Reagent \u201cIMG\u201d Kit for serum, when used in conjunction with Beckman Coulter Immage\u00ae 800 Analyzer, is intended for the quantitative determination of Retinol Binding Protein (RBP) in human serum.<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    <\/td>\nKR<\/strong><\/td>\nK<\/strong><\/td>\n<\/tr>\n
    Antiserum Reagent<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein – Serum<\/td>\nR.IMG.RBP-S<\/td>\n1 vial \u2013 3,5 ml<\/td>\n\u25cf<\/span><\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Accessory Reagent<\/strong><\/td>\n<\/tr>\n
    Reagent \u201cB\u201d RBP<\/td>\nR.IMG.RBP.B<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25cf<\/span><\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Calibrators<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein<\/td>\nW.SPC.RBP<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Prediluted Calibrator Set
    \nRetinol Binding Protein
    \nSet of ready-to-use Calibrators<\/td>\n    		W.SET.SPC.RBP<\/td>\n5 vials \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Controls<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein – Serum
    \nMedium Value<\/td>\n    		Y.SPR.RBP.MV<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Retinol Binding Protein – Serum
    \nLow Value<\/td>\n    		Y.SPR.RBP.LV<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Retinol Binding Protein – Serum
    \nMedium Value<\/td>\n    		Y.SPR.RBP.MV-3<\/td>\n3 vials \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Retinol Binding Protein – Serum
    \nLow Value<\/td>\n    		Y.SPR.RBP.LV-3<\/td>\n3 vials\u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Key<\/strong><\/em><\/td>\n<\/tr>\n
    \u25cf<\/span><\/td>\nReagents included in the kit.<\/td>\n<\/tr>\n
    \u25ac<\/td>\nCorrelated reagents not included in the kit. They are available separately.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n\n\n\n\n\n\n
    \n
    RBP – Urine<\/strong><\/h5>\n<\/td>\n<\/tr>\n
    <\/td>\nProduct code<\/strong><\/td>\n<\/tr>\n
    KR<\/strong><\/td>\nKR.IMG.RBP-U<\/td>\nReagent Kit (Calibrator and controls not included)<\/td>\n<\/tr>\n
    K\u00a0<\/strong><\/td>\nK.IMG.RBP-U<\/td>\nComplete Kit<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    The Retinol Binding Protein (RBP) Reagent \u201cIMG\u201d Kit for urine, when used in conjunction with Beckman Coulter Immage\u00ae 800 Analyzer, is intended for the quantitative determination of Retinol Binding Protein (RBP) in human urine.<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    <\/td>\nKR<\/strong><\/td>\nK<\/strong><\/td>\n<\/tr>\n
    Antiserum Reagent<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein – Urine<\/td>\nR.IMG.RBP-U<\/td>\n1 vial \u2013 4,7 ml<\/td>\n\u25cf<\/span><\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Accessory Reagent<\/strong><\/td>\n<\/tr>\n
    Reagent \u201cB\u201d RBP<\/td>\nR.IMG.RBP.B<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25cf<\/span><\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Calibrators<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein<\/td>\nW.SPC.RBP<\/td>\n1 vial \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Prediluted Calibrator Set
    \nRetinol Binding Protein
    \nSet of ready-to-use Calibrators<\/td>\n    		W.SET.SPC.RBP<\/td>\n5 vials \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Controls\u00a0<\/strong><\/td>\n<\/tr>\n
    Retinol Binding Protein – Urine
    \nMedium Value<\/td>\n    		Y.UPR.RBP.MV<\/td>\n1 vial\u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Retinol Binding Protein – Urine
    \nLow Value<\/td>\n    		Y.UPR.RBP.LV<\/td>\n\u00a01 vial\u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Retinol Binding Protein -Urine
    \nMedium Value<\/td>\n    		Y.UPR.RBP.MV-3<\/td>\n3 v \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Retinol Binding Protein – Urine
    \nLow Value<\/td>\n    		Y.UPR.RBP.LV-3<\/td>\n3 fiale \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Key<\/strong><\/em><\/td>\n<\/tr>\n
    \u25cf<\/span><\/td>\nReagents included in the kit.<\/td>\n<\/tr>\n
    \u25ac<\/td>\nCorrelated reagents not included in the kit. They are available separately.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/form>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Retinol Binding Protein Retinol-binding protein (RBP) is a single polypeptide chain, with a molecular weight of about 21-kDa, that is […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1176","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/comments?post=1176"}],"version-history":[{"count":27,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1176\/revisions"}],"predecessor-version":[{"id":2212,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1176\/revisions\/2212"}],"wp:attachment":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/media?parent=1176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}