{"id":1147,"date":"2022-03-11T18:44:45","date_gmt":"2022-03-11T17:44:45","guid":{"rendered":"https:\/\/newscientific.eu\/c3pa\/"},"modified":"2025-05-15T11:42:33","modified_gmt":"2025-05-15T09:42:33","slug":"c3pa","status":"publish","type":"page","link":"https:\/\/newscientific.eu\/en\/c3pa\/","title":{"rendered":"PFB (GBG)"},"content":{"rendered":"
\n

Properdin Factor B<\/h2>\n

The complement system Factor B (FB), also known as C3 Proactivator (C3PA), Properdin Factor B (PFB) or Glycinerich Beta Glycoprotein (GBG), is a glycoprotein that circulates in the blood as a single chain polypeptide with an approximate molecular weight of 93 KDa.
\nFB is a centrally component of the alternative complement pathway. The activation of this pathway results in factor B cleavage and production of the amino-terminal Ba and the carboxyl-terminal Bb fragments which have a role as cofactors in antibody-independent monocyte-mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes (1).
\nFactor B hyperconsumption and increased catabolism (that lead to decreased level of this protein in serum), concomitant with factor B fragments production, occurs in several conditions including gram-negative sepsis, kidney diseases (such as chronic glomerulonephritis or lupus nephritis), skin diseases (such as dermatitis herpetiformis or pemphigus vulgaris), autoimmune diseases and sickle cell anaemia (2).
\nMoreover the genetic Factor B deficiency, a rare condition, determines an increased susceptibility to bacterial infections, particularly Neisseria infections and Streptococcus pneumoniae, due to a defect in the alternative complement pathway activation. (3).<\/p>\n

Reference<\/em><\/p>\n

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  1. Pekna , Hietala , Landin , Nilsson , Lagerberg, , Betsholtz, and Pekny, (1998), Mice Deficient for the Complement Factor B Develop and Reproduce Normally. Scandinavian Journal of Immunology, 47: 375-380.<\/em><\/li>\n
  2. Kolb W, P, Morrow P, R, Tamerius J, D: Ba and Bb Fragments of Factor B Activation: Fragment Production, Biological Activities, Neoepitope Expression and Quantitation in Clinical Samples. Complement Inflamm 1989;6:175-204.<\/em><\/li>\n
  3. Aradottir SS, Kristoffersson AC, Roumenina LT, Bjerre A, Kashioulis P, Palsson R, Karpman D. Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis. Front Immunol. 2021 Jun 10;12:690821.<\/em><\/li>\n<\/ol>\n<\/div>\n

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    Search IFU<\/strong><\/span><\/h4>\n

    <\/p>\n


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    \n
    \n<\/form>\n

    *Mandatory field<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n
    \n

    For Siemens BN\u2122 series Analyzer<\/strong><\/span><\/h4>\n<\/td>\n<\/tr>\n

    <\/td>\nProduct code<\/strong><\/td>\n<\/tr>\n
    KR<\/strong><\/td>\nKR.BNA.GBG-2<\/td>\nReagent Kit (Calibrator and controls not included)<\/td>\n<\/tr>\n
    K<\/strong><\/td>\nK.BNA.GBG-2<\/td>\nComplete Kit<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    The Properdin Factor B (PFB, GBG, C3PA) \u201cBNA\u201d Kit, when used in conjunction with Siemens “BN\u2122 series” Analyzers (BNA, BN100, BNII, ProSpec), is intended for the quantitative determination of Properdin Factor B in human serum.<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    <\/td>\nKR<\/strong><\/td>\nK<\/strong><\/td>\n<\/tr>\n
    Antiserum Reagent<\/strong><\/td>\n<\/tr>\n
    Properdin Factor B<\/td>\nR.BNA.GBG-2<\/td>\n1 vial \u2013 4 ml<\/td>\n\u25cf<\/span><\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Calibrator<\/strong><\/td>\n<\/tr>\n
    Complement system proteins<\/td>\nW.SPC.CS1<\/td>\n1 vial\u00a0 \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Controls<\/strong><\/td>\n<\/tr>\n
    Complement system proteins
    \nMedium Value<\/td>\n    		Y.SPR.CS1.MV<\/td>\n1 vial\u00a0 \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Complement system proteins
    \nLow Value<\/td>\n    		Y.SPR.CS1.LV<\/td>\n1 vial\u00a0 \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25cf<\/span><\/td>\n<\/tr>\n
    Complement system proteins
    \nMedium Value<\/td>\n    		Y.SPR.CS1.MV-3<\/td>\n3 vials \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Complement system proteins
    \nLow Value<\/td>\n    		Y.SPR.CS1.LV-3<\/td>\n3 vials \u2013 1 ml<\/td>\n\u25ac<\/td>\n\u25ac<\/td>\n<\/tr>\n
    Key<\/strong><\/em><\/td>\n<\/tr>\n
    \u25cf<\/span><\/td>\nReagents included in the kit.<\/td>\n<\/tr>\n
    \u25ac<\/td>\nCorrelated reagents not included in the kit. They are available separately.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Properdin Factor B The complement system Factor B (FB), also known as C3 Proactivator (C3PA), Properdin Factor B (PFB) or […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1147","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/comments?post=1147"}],"version-history":[{"count":15,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1147\/revisions"}],"predecessor-version":[{"id":2220,"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/pages\/1147\/revisions\/2220"}],"wp:attachment":[{"href":"https:\/\/newscientific.eu\/en\/wp-json\/wp\/v2\/media?parent=1147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}